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Langefeld, Carl
One or more keywords matched the following items that are connected to Langefeld, Carl
Item TypeName
Academic Article Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension.
Academic Article Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus.
Academic Article Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression.
Academic Article Power for genetic association studies with random allele frequencies and genotype distributions.
Academic Article Ordered subset analysis in genetic linkage mapping of complex traits.
Academic Article T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Academic Article Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.
Academic Article P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study.
Academic Article Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect.
Academic Article Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12.
Academic Article Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus.
Academic Article A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.
Academic Article Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
Academic Article Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population.
Academic Article Association methods in human genetics.
Academic Article Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease.
Academic Article Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study.
Academic Article Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
Academic Article High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
Academic Article Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
Academic Article The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.
Academic Article Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study.
Academic Article A polymorphism within IL21R confers risk for systemic lupus erythematosus.
Academic Article European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.
Academic Article Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: The IRAS Family Study.
Academic Article Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report.
Academic Article Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.
Academic Article Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Academic Article Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
Academic Article Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study.
Academic Article The role of genetic variation near interferon-kappa in systemic lupus erythematosus.
Academic Article Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.
Academic Article Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes.
Academic Article Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
Academic Article Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
Academic Article Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.
Academic Article Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study.
Academic Article Common variants in the periostin gene influence development of atherosclerosis in young persons.
Academic Article Meta-analysis of genome-wide linkage scans for renal function traits.
Academic Article Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.
Academic Article Identification of ATPAF1 as a novel candidate gene for asthma in children.
Academic Article Genome-wide association of BMI in African Americans.
Academic Article Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans.
Academic Article Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Academic Article Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.
Academic Article Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy.
Academic Article Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
Academic Article Evaluation of TRAF6 in a large multiancestral lupus cohort.
Academic Article Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.
Academic Article Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.
Academic Article Genetic ancestry, serum interferon-a activity, and autoantibodies in systemic lupus erythematosus.
Academic Article Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations.
Academic Article Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
Academic Article Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease.
Academic Article Informed conditioning on clinical covariates increases power in case-control association studies.
Academic Article Risk factors for intracerebral hemorrhage differ according to hemorrhage location.
Academic Article MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.
Academic Article Heritability of carotid artery intima-medial thickness in type 2 diabetes.
Academic Article Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.
Academic Article Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage.
Academic Article A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage.
Academic Article A genome scan for diabetic nephropathy in African Americans.
Academic Article A genome scan for ESRD in black families enriched for nondiabetic nephropathy.
Academic Article Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population.
Academic Article Multilocus and interaction-based genome scan for alcoholism risk factors in Caucasian Americans: the COGA study.
Academic Article Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study.
Academic Article Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations.
Academic Article Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE.
Academic Article A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
Academic Article Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.
Academic Article Genetic variation in the CRP promoter: association with systemic lupus erythematosus.
Academic Article Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy.
Academic Article Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Academic Article Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study.
Academic Article Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
Academic Article Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study.
Academic Article Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.
Academic Article Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease.
Academic Article Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).
Academic Article Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
Academic Article INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.
Academic Article An algorithm for learning maximum entropy probability models of disease risk that efficiently searches and sparingly encodes multilocus genomic interactions.
Academic Article Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15.
Academic Article Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.
Academic Article The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
Academic Article The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.
Academic Article Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Academic Article Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.
Academic Article The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Academic Article Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.
Academic Article A genome-wide association study for diabetic nephropathy genes in African Americans.
Academic Article Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.
Academic Article Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.
Academic Article Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.
Academic Article Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.
Academic Article Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
Academic Article Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans.
Academic Article Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to mothers of children with neonatal lupus.
Academic Article Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.
Academic Article A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.
Academic Article A genome-wide association search for type 2 diabetes genes in African Americans.
Academic Article Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans.
Academic Article Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
Academic Article Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.
Academic Article Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease.
Academic Article Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.
Academic Article Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.
Academic Article Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage.
Academic Article Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.
Academic Article Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans.
Concept Genetic Predisposition to Disease
Academic Article A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Academic Article Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Academic Article Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study.
Academic Article Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.
Academic Article Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.
Academic Article PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
Academic Article Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Academic Article Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.
Academic Article JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy.
Academic Article Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans.
Academic Article Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk.
Academic Article Gene-gene interactions in APOL1-associated nephropathy.
Academic Article A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND).
Academic Article End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Academic Article Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease.
Academic Article Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study.
Academic Article Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.
Academic Article Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
Academic Article Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.
Academic Article Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Academic Article Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans.
Academic Article The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease.
Academic Article Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study.
Academic Article Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression.
Academic Article Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study.
Academic Article Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
Academic Article Rare Coding Variation and Risk of Intracerebral Hemorrhage.
Academic Article Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).
Academic Article Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression.
Academic Article Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
Academic Article Genetics of autoimmune diseases: insights from population genetics.
Academic Article Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.
Academic Article A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).
Academic Article Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.
Academic Article HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Academic Article Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Academic Article Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Academic Article Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).
Academic Article Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.
Academic Article Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.
Academic Article Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.
Academic Article Genetic variants in CETP increase risk of intracerebral hemorrhage.
Academic Article Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
Academic Article Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study.
Academic Article Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.
Academic Article Genetic epidemiology in kidney disease.
Academic Article Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Academic Article A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.
Academic Article Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
Academic Article Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.
Academic Article Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.
Academic Article Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Academic Article Trans-Ethnic Mapping of BANK1 Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks.
Academic Article Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.
Academic Article Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Academic Article Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.
Academic Article A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Academic Article Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
Academic Article Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
Academic Article Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.
Academic Article GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Academic Article Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.
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  • Genetic Predisposition to Disease